The 12 Best Anti-Aging Serums and How They Work, According to a Dermatologist

Women doing skincare in ornate mirror.

We The People

Deciphering all the products in the skincare section at a beauty store can be as difficult as learning a foreign language. Between all the cleansers, masks, toners, serums, lotions, and potions, how are we supposed to decide which ones we need, and of those essentials, which options are best? Indeed, developing a comprehensive, personalized skincare routine is intimidating, especially if it's unfamiliar territory.

As we start thinking about more specialized products that target certain concerns, it is easy to become overwhelmed. So, to start, we decided to unpack one of the most essential and elusive items: serums that ward off signs of aging and promote a youthful glow.

To learn more about the basics and to ease the selection process, we reached out to dermatologist Ronald Moy, MD, a partner at Moy-Fincher-Chipps Facial Plastics & Dermatology. Read through Moy's step-by-step lesson in everything you should know about serums as well as his anti-aging advice below. Then, scroll on for the 12 best anti-aging serums and decide which to add to your skincare lineup based on specific needs and price point.

Meet the Expert

Ronald Moy, M.D., is a research-driven dermatologist based in Beverly Hills with specialties in plastic surgery and dermatology. He is a partner at Moy-Fincher-Chipps Facial Plastics & Dermatology and founder of the DNA-EGF Renewal line of skincare products.

Understanding the Basics

While most of us know we need to pile on some sort of moisturizer after washing our faces, serum seems a bit more obscure. If there's no immediate impact on our skin, what's the price tag for?

In reality, serum is much different from a moisturizer—and it's just as important a step in your skincare routine. Moy sets the record straight, explaining that "Serum is a clear, non-greasy formula designed so the active ingredients penetrate deeply into your skin, while a moisturizer is typically a greasy formula designed to moisturize the top layer of the skin." Even though serum does provide moisturizing benefits, you still should use a moisturizer on top so the long-term benefits are at their most effective.

The costs of effective anti-aging creams and serums are usually less than $150. As long as they have ingredients that help repair damage and boost the skin's regenerative process, it's worth the extra buck.

Regular Serum vs. Anti-Aging Serum

Serums, in general, are great for targeting specific concerns, but it depends on which active ingredients your skin needs to look and feel healthier. For example, you may want to fight acne, while someone else may be looking for one with inflammatory benefits. As for anti-aging serums, they work on a cellular level to repair the DNA damage that occurs from sunlight, pollution, and even blue light from computers and phones, according to Moy.

These particular serums help boost the skin's ability to repair itself while protecting it, so you can see long-term results rather than just the immediate payoff. "Anti-aging means that you're choosing to use ingredients that help repair different types of damage that have been shown to accelerate the signs aging," Moy says. "From sun damage to thinning skin, it's so important to be preventative with your skincare."

When Should You Start?

If you're wondering when you can start benefiting from an anti-aging serum, there is no rule of thumb. "The biggest anti-aging culprit is the sun, so you should really start using serums or moisturizers that have anti-aging properties when sun damage occurs at any age," Moy says. You can start using it as early as you want in order to take preventative measures or you can start using it later in the game to reduce the appearance of fine lines and thinning and to restore a youthful glow. As long as you choose one that has DNA-repairing enzymes, you'll be on the right track.

And on that note, check out Moy's recommendations, as well as 10 more top-sellers below to decide which of the best anti-aging serums you want to integrate into your skincare routine.

01 of 12

RMD DNA Regeneration Serum

Moy recommends this regenerating serum, which accelerates the growth of healthy skin cells to improve complexion and reduce overall signs of premature aging. 

RMD DNA Regeneration Serum $145
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02 of 12

Estée Lauder Advanced Night Repair

Also recommended by Moy, this night serum by Estée Lauder is a great option for your evening routine, as it works to renew and prepare your skin while you sleep.

Advanced Night Repair Synchronized Recovery Complex II
Estée Lauder Advanced Night Repair Synchronized Recovery Complex II $75
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03 of 12

TruSkin Vitamin C Serum

This super-affordable anti-aging serum is the best seller on Amazon, which means that it also happens to be easy to get.

TruSkin Naturals Vitamin C Serum for Face
TruSkin Vitamin C Serum for Face, 1 Oz. $20
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04 of 12

Ren Skincare Bio Retinoid Anti-Ageing Concentrate

Derived from vitamin and pro-vitamin A, it delivers the same benefits of retinol without causing any irritation if your skin is sensitive.

Bio Retinoid Anti-ageing Concentrate
Ren Skincare Bio Retinoid Anti-Ageing Concentrate $69
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05 of 12

Vintner's Daughter Active Botanical Serum

With 22 active ingredients, this serum pretty much does it all, from fighting signs of aging to clearing up blemishes and creating a more even tone by promoting cellular turnover and undoing the damage caused by free radicals. 

Active Botanical Serum
Vintner's Daughter Active Botanical Serum, 30ml $185
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06 of 12

Joelle Ciocco Serial Booster Anti-Aging Serum

This French anti-aging serum works to speed up the skin cell restoration process as well as smoothing out fine lines with continued use and strengthening your skin against oxidative stress. 

Joelle Ciocco Serial Booster Anti-Aging Serum $136
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07 of 12

Tracie Martyn Facial Resculpting Firming Serum

This serum is on the lighter side, but it's also incredibly moisturizing and strengthening to promote radiance and more skin elasticity where collagen has been depleted. 

Facial Resculpting Firming Serum
Tracie Martyn Facial Resculpting Firming Serum $195
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08 of 12

Zelens Youth Concentrate Supreme Age-Defying Serum

When it comes to high-end, powerful skincare products that don't require a prescription, it's hard to beat Zelens. Everything in the line was developed by Dr. Marko Lens, who studied based on a Nobel-prize winning discovery of the role of telomeres in controlling skin’s aging process. A complex of eight peptides and encapsulated retinol works to help increase the life and vitality of skin cells and to significantly reduce all visible signs of aging. 

Women's Youth Concentrate Supreme Age-Defying Serum
Zelens Youth Concentrate Supreme Age-Defying Serum $193
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09 of 12

Osea Hyaluronic Sea Serum

This lightweight, non-greasy serum smoothes wrinkles and fine lines while also delivering deep moisture to plump up dry and dull skin. It's a great organic, natural product. 

Osea Hyaluronic Sea Serum $88
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10 of 12

La Roche-Posay Anti-Aging Serum

If you're wondering if there's a solid anti-aging serum option at your local drugstore, here's your answer (it's good news). Available at most drugstores, La Roche-Posay has been approved by dermatologists and sits within a more comfortable price range than other effective anti-aging serums. 

La Roche-Posay Effaclar Pore-Refining Anti-Aging Serum $45
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L:A Bruket Broccoli Seed Serum

This Swedish line uses all organic ingredients and falls within a more affordable price range. Its broccoli seed serum is packed with vitamin C, which naturally stimulates cell renewal.

Facial Serum
L:A Bruket Broccoli Seed Serum $62
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Sunday Riley

While not a serum per se, this lactic acid formula from Sunday Riley is an incredible addition to your skincare routine since it exfoliates dead skin cells to make room for your fresher, younger-looking skin to find its way to the surface. This leave-on treatment goes under your moisturizer like a serum would and plumps the skin to reduce fine lines and create more radiance. 

Lactic Acid Treatment
Sunday Riley Good Genes All-in-One Lactic Acid Treatment $122
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Article Sources
MyDomaine uses only high-quality, trusted sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Yarosh DB, Rosenthal A, Moy R. Six Critical Questions for DNA Repair Enzymes in Skincare Products: A Review in DialogClin Cosmet Investig Dermatol. 2019;12:617-624.

  2. Buckingham EM, Klingelhutz AJ. The Role of Telomeres in the Ageing of Human Skin: Telomeres and Skin AgeingExperimental Dermatology. 2011;20(4):297-302. doi:10.1111/j.1600-0625.2010.01242.x

  3. Juliet Pullar, Anitra Carr, Margreet Vissers. The Roles of Vitamin C in Skin HealthNutrients. 2017;9(8):866. doi:10.3390/nu9080866

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